Orphan: First Kill is a 2022 psychological horror film that serves as a prequel to the 2009 film Orphan. Directed by William Brent Bell, it was written by David Coggeshall, based on a story by David Leslie Johnson-McGoldrick and Alex Mace (who wrote the screenplay and story to the predecessor, respectively). Financed by eOne, Dark Castle Entertainment, Sierra/Affinity, and Eagle Vision, it stars Isabelle Fuhrman reprising her role from the previous film, with Julia Stiles , Rossif Sutherland, Hiro Kanagawa, and Matthew Finlan also starring.

Originally with the working title of Esther, the project was announced in February 2020. The official title was revealed in November that same year, with Fuhrman reprising her role as Esther. Filming took place in Winnipeg from November to December 2020.

Orphan: First Kill premiered first in other territories starting in the Philippines on July 27, 2022, and was released in the United States on August 19, 2022, by Paramount Players in select theatres, digital, and streaming via Paramount+. Critics praised the film’s twists, practical effects (in regard to de-aging Fuhrman without CGI), and Fuhrman’s performance, but some criticized its story and inconsistencies.

On January 26, 2007, Estonian psychiatric patient Leena Klammer—a 31-year-old woman with a rare hormonal disorder called hypopituitarism that gives her the appearance of a 9-year-old child—orchestrates an escape from the Saarne Institute by seducing and killing a guard and hiding in the car of Anna, an art therapist. After breaking into Anna’s house and killing her, Leena looks up missing American girls and finds that she bears resemblance to a girl named Esther Albright, who went missing in 2003. Posing as a lost girl, a police officer approaches Leena and she introduces herself as “Esther”, claiming that her parents are in the United States.